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The quantitative luminescent kinase assay ADP-Glo™ was used to screen CK2 inhibitors from the natural product library.
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To identity novel classes of inhibitors for CK2, we screened a natural product library obtained from National Cancer Institute. CK2 overexpression is associated with multiple human cancers and may therefore be a promising target for cancer therapy. Casein kinase 2 (CK2) is involved in various cellular events such as proliferation, apoptosis, and the cell cycle.
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